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How Do I Choose a Sampler?


This is one of the most common questions we are asked. Even though there is no direct answer as every situation is different there are numerous factors that need to be considered when deciding on the best sampler. Usually poor sampling results are a direct result of not choosing the correct tool. For example a common mistake is a free flowing powder sampler is used when the powder being sampled is poor flowing (more on this later).



The reasons for sampling can be anything from goods in checking, sample retention to final quality testing. Clarity is needed at this point.
For example if you are carrying out particle size analysis sampling using a scroll type of sampler will give you poor results. In effect the powder will be milled leading to poor results and the possibility of a batch being needlessly rejected.
Other reasons for sampling could be microbiological testing. Therefore the use of a presterilised sampler or a sampler that can be easily sterilised will be critical.
The reason for sampling is critical on the choice of sampler.


Even though this sounds obvious it is the most common mistake. The choice of the correct sampler is critical otherwise you will end up with poor results.

Powder Sampling – Powder characteristic range hugely. Some powders are very flowing others flow very poorly. Poor flowing powders are generally harder to sample but you need the right equipment to make it a success. Many samplers rely on the powder to flow into the sampler. If the powder is not free flowing it will not work properly. Therefore a quick test to see what type of powder you have is the "co test". Simply push a clean cylinder or gloved finger into the powder. If the powder falls in on itself it is free flowing. If it is cohesive there will be the shape of the finger or cylinder left in the powder

Granule Sampling – How large are the granules? Some samplers can have small sampling holes. Will the granules fit in the sampler?

Liquid and Viscous Sampling – What is the viscosity of the medium? Again choosing the correct device is critical. Many viscous samplers are no good for liquids and vice versa.


A proper understanding is critical.

Headroom – Is there enough headroom above the machine, container etc for sampling? If you are sampling in a glove box or other confined space is the sampler small enough?

Cleaning Facilities – Is there the ability to clean down the sampler after use or should a single use SteriWare® sampler be used?

Location – Is the sampler to be fitted to a machine or is it manual sampling. Can the area be easily accessed?


What does the sampler have to be made from needs to be considered.

  • Is the material being sampled corrosive.
  • Will the material being sampled react with the sampler
  • What is the contact time of the material in the sampler

Chemical resistance charts are very useful. They give a good indication on which material is suitable. A chemical resistance chart is available at the end of our brochure. However care needs to be taken when choosing disposable samplers. Chemical resistance charts are based on prolonged contact over weeks or months. Single use samplers may appear not suitable but because the contact time is only seconds they will often be suitable. Further investigations and testing may need to be carried out.


Traditionally reusable samplers have been the sampler of choice primarily due to the lack of disposable samplers available. However due to the development in disposable samplers by Sampling Systems they are now preferred by many Pharmaceutical, Chemical & Food companies.

Advantages of Reusable Samplers:

  • 1 off cost and the sampler can be resued.
  • They are often stronger than disposables so if the medium is dense/hard they are more likely to go to the required depth

Advantages of Single Use SteriWare® Samplers:

  • No cleaning costs
  • No cleaning validation costs
  • Speed – simply unwrap and use
  • No risk of cross contamination


The design of the sampler needs to be suitable for the application. It is pointless buying a plastic sampler if you are sampling a hard material as it will simply bend. For powder samplers the tip should be considered in relation to how cohesive the powder is.


Other considerations include the ease of cleaning. If you need a sampler that needs to be properly cleaned it needs to be easily stripped to its components and designed for cleaning. Features to look out for include fully welded construction as opposed to spot welding. For critical applications is weld or electropolishing required.

SteriWare® Disposable Samplers remove the requirement of cleaning making them increasingly popular with many customers.


How easy is it to remove the sample after sampling? For some this is critical when "unit dose sampling", sampling very small amounts or sampling very expensive material.

When taking small samples it is important that the sample is reproducible time and time again, but also that the full sample is removed to allow for a constant volume.


Metal and stainless steel samplers can have different surafce finishes. Generally if you are looking for something that is easy to clean, surface that powder does not stick to so easily then a sampler with a very smooth surface finish will be required. Traditionally this has been called a mirror polish. However this is now classed as an Ra finish.

Satin Finish = Less than < 1 Ra
Mirror Finish = Less than < 0.2Ra

We suggest check the surface finish on the specification sheet before ordering. If required the finish can generally be improved to the desired level; contact us for more information.

Electropolishing is a common option which has 2 main advantages.  Firstly it cleans the sampler and polishes the sampler in often difficult places such as the internal bore of tube. Secondly it generally improves the surface finish (reduces the Ra) and gives a sample a more "polished" look.


What documentation is required with the sampler? Is it simply a generic certificate of conformity or are other certs required? For example:

Reusable Samplers:

  • General certificate of conformity
  • Certificate of conformity that relates directly to your order
  • Material certification. XRF certification
  • Surface finish certificate – Ra certification
  • Welder certification

Disposable Samplers:

  • Sterilisation certification
  • Batch specific documentation
  • BSE/TSE documentation
  • EC/EU & FDA certification



If the powder or liquid is flammable or liable to create sparks (such as fuel) it is imperative that the correct device be chosen. Earthing the sample must be carried out or buying a sampler that has been proven for use in ATEX, EX areas should be carried out. A risk assessment should be carried out.

Some customers have also found that earthing the sampler (even if not required) because of electrostatics helps improve the results.


There are general practices which should be considered before, during and after:

How can I minimise sample handling?

When taking a sample the number of times it is transferred between containers should be minimised. Each time the sample is transferred small amounts of sample are left behind and there is a greater risk of contamination which could lead to poor results.

What am I Storing the Sample In?

Again an assessment should be carried out on what the sample is being put in. The correct container or bag will make sampling easier but also keep the sample safe. Some samples can be retained for many years so it is important to check that the container is suitable for this period of time. Other common considerations include does the container have to be sterile, what standard of sterility or cleanliness is required, size of container.
Advantages of Containers: Usually stronger & widely available in different sizes and shapes
Advantages of Bags: Use less space & cheaper


A risk assessment of the sampling area and process should be carried out. Very hazardous materials are frequently sampled and it Is important that not only the correct tools are used but the whole process of sampling be assessed

  • Adequate ventilation
  • Correct PPE is worn
  • Adequate lighting
  • Enough space
  • Proper training of procedures

We hope that the above guide to how do I take a sample is helpful. The guide is meant to give brief overview of common questions and concerns we have found over the last 25 years. 

If you have questions or comments please do not hesitate to ask Jonathan Fenner at jonathan.fenner@sampling.com